2018

Jimenez JC, Su K, Goldberg AR, Luna VM, Biane JS, Ordek G, Zou P, Ong SK, Wright MA, Zweigel L, Paninski L, Hen R,  Kheirbek MA (2018) Anxiety cells in a hippocampal-hypothalamic circuit.  Neuron 97:670-683 (PDF/highlight Nature Reviews Neuro/NPR/CBC/Science Alert)

Zhou P, Resendez SL, Rodriguez-Romaguera J, Jimenez JC, Neufeld SQ, Giovannucci A, Friedrich  J, Pnevmatikakis EA, Stuber GD, Hen R, Kheirbek MA, Sabatini BL, Kass RE, Paninski L (2018) Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data.  eLife 6:e28128 (PDF)

Stefanini F*, Kheirbek MA*, Kushnir L*, Jennings JH, Stuber GD, Hen R, Fusi S.  A distributed neural code in ensembles of dentate gyrus granule cells. bioRxiv.  *equal contribution  (PDF)

2017

Tritschler L, Kheirbek MA, Dantec YL, Mendez-David I, Guilloux JP, Faye C, Doan J, Pham TH, Hen R, David DH, Gardier AM. (2018) Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the nucleus accumbens.  Neurosci Res.  Dec 12, PMID 2926683

Woods NI, Kheirbek MA (2017) The small world of a fear memory.  Neuron 94(2):226-227 (PDF)

Biane JS, Kheirbek MA (2017) Imaging adult hippocampal neurogenesis in vivo.  Neuropsychopharmacology 42:373 (PDF)

2016

Tannenholz L, Hen R, Kheirbek MA (2016) GluN2B-containing NMDA receptors on adult-born granule cells contribute to the antidepressant action of fluoxetine. Frontiers in Neuroscience, 10:242 (PDF)

Carvalho Poyraz F, Holzner E, Bailey MR, Meszaros J, Kenney L, Kheirbek MA, Balsam PD, Kellendonk C. (2016) Decreasing striatopallidal pathway function enhances motivation by energizing the initiation of goal-directed action. Journal of Neuroscience. 36(22):5988-600. (PDF)

Danielson NB, Kaifosh P, Zaremba JD, Lovett-Barron M, Tsai J, Denny CA, Balough EM, Goldberg AR, Drew DJ, Hen R, Losonczy A, Kheirbek MA (2016) Distinct contribution of adult-born hippocampal granule cells to context encoding.  Neuron. 90(1):101-112 (PDF/preview/best of Neuron)  
 

2015

Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R. (2015) Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons. Hippocampus, 2015 Dec 14. doi: 10.1002/hipo.22557. (PDF)

Kheirbek MA  (2015) Finding the roots of adult neurogenesis. Cell 161 (7):1500-1502. (PDF)

Borgkvist A, Avegno EM, Wong MY, Kheirbek MA, Sonders MS, Hen R, Sulzer D. (2015) Loss of striatonigral GABAergic presynaptic inhibition enables motor sensitization in parkinsonian mice. Neuron. 87(5):976-88. (PDF)

Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa A, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Kang H, Caldwell J, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar D, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders A, Manieri N, Muthupalani A, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC. (2015) Gremlin 1 identifies a skeletal stem cell with bone, cartilage and reticular stromal potential. Cell  160, 269-284. (PDF)

2014

Denny CA, Kheirbek MA, Alba EL, Tanaka, KF, Brachman RA, Laughman KB, Tomm NK, Turi GF, Losonczy A & Hen R (2014) Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron, 83, 189-201. (PDF)

Kheirbek MA & Hen R (2014) Add neurons, subtract anxiety. Scientific American, 311, 62-67. (PDF)

Lovett-Barron M, Kaifosh P, Kheirbek MA, Danielson N, Zaremba JD, Reardon TR, Turi GF, Hen R, Zemelman BV, Losonczy A. (2014) Dendritic inhibition in the hippocampus supports fear learning. Science 343. (857-63). (PDF)

Tannenholz  L, Jimenez JC, Kheirbek MA (2014) Local and regional heterogeneity underlying hippocampal modulation of cognition and mood. Frontiers in Behavioral Neuroscience8, 147. (PDF)

2013

Kheirbek MA, Drew LJ, Costantini DO, Burghardt N, Tannenholz L, Ahmari SE, Zeng H, Fenton AA, Hen R (2013) Differential control of learning and anxiety along the dorso-ventral axis of the dentate gyrus, Neuron, 77: 955-968. (PDF/preview)

Ahmari SE, Spellman T, Douglass N, Kheirbek MA, Deisseroth K, Gordon JA, Hen R (2013) Repeated corticostriatal stimulation generates persistent OCD-like behavior. Science 340, 1234-1239. 

Kheirbek MA, Hen R (2013) (Radio)active neurogenesis in the human hippocampus. Cell 153, 1183-1184. (PDF)

2012

Kheirbek MA, Tannenholz, L. & Hen, R. (2012) NR2B-Dependent Plasticity of Adult-Born Granule Cells is Necessary for Context Discrimination. Journal of Neuroscience, 32, 8696-8702. (PDF)

Kheirbek MA, Klemenhagen KK, Sahay A, Hen R (2012) Neurogenesis and generalization: a new approach to stratify and treat anxiety disorder. Nature Neuroscience 2012 Dec;15(12):1613-20. (PDF)

2011

Sahay A, Scobie KN, Hill SH, O’Carroll CM, Kheirbek MA, Burghardt N, Fenton AA Dranovsky A Hen R. (2011) Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature, 472 (7344): 466-70.  PMCID: PMC3084370. (PDF)            

2010

Kheirbek MA, Hen R (2010) Neurogenesis in the dorsal and ventral hippocampus: contribution to cognition and mood. Neuropsychopharmacology. Jan;36(1):373-4. (PDF)

Kheirbek MA, Beeler JA, Chi W, Zhuang X (2010).  A molecular dissociation between cued and contextual appetitive learning. Learning and Memory, 17: 148-154 PMCID: PMC2832921. (PDF) 

Beeler JA, Cao ZFH, Kheirbek MA, Ding Y, Koranda J, Murakami M,  Zhuang X. (2010) Dopamine-dependent motor learning: insight into L-DOPA’s long-duration response. Annals of Neurology, 67(5):639-47. (PDF)

2009

Kheirbek MA*, Britt JP*, Beeler JA, Ishikawa Y, McGehee DS, Zhuang X. (2009)  Adenylyl cyclase type V contributes to corticostriatal plasticity and striatum dependent motor learning. Journal of Neuroscience, 29: 12115 – 12124 PMCID: PMC2782774. (PDF)

Beeler JA, Cao ZFH, Kheirbek MA, Zhuang X. (2009) Dissociation of reinforcement and locomotor effects of cocaine in Pitx3 deficient mice. Neuropsychopharmacology, 34(5):1149-61. PMCID: PMC2752723. (PDF)

2008

Kheirbek MA, Beeler JA, Ishikawa Y, Zhuang X.  (2008) A cyclic AMP pathway required for reward prediction in associative learning. Journal of Neuroscience 28:11401-11408. PMCID: PMC2610269. (PDF)

2002-2007

Kheirbek MA (2007) A molecular switch for induction of long-term depression of corticostriatal transmission. Journal of Neuroscience 27:9824-9825. (PDF)

Hale ME, Kheirbek MA, Schriefer JE, Prince VE (2004) Hox gene misexpression and cell-specific lesions reveal functionality of homeotically transformed neurons. Journal of Neuroscience 24:3070-3076. (PDF) 

McClintock JM, Kheirbek MA, Prince VE (2002) Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention. Development 129:2339-2354. (PDF)